CD163
نویسندگان
چکیده
منابع مشابه
Soluble ectodomain CD163 and extracellular vesicle-associated CD163 are two differently regulated forms of ‘soluble CD163’ in plasma
CD163 is the macrophage receptor for uptake of hemoglobin-haptoglobin complexes. The human receptor can be shed from the macrophage surface owing to a cleavage site for the inflammation-inducible TACE/ADAM17 enzyme. Accordingly, plasma 'soluble CD163' (sCD163) has become a biomarker for macrophage activity and inflammation. The present study disclosed that 10% of sCD163 in healthy persons is ac...
متن کاملSoluble CD163 Levels and CD163+CD14+ Monocyte/Macrophage Counts in Patients with Asthma
Background: CD163-expressing macrophages are involved in the inflammatory response in asthma. Objective: To assess sputum and serum soluble CD163 (sCD163) and cytokine levels in patients with asthma. Further discussed was the difference between sCD163 and other classic inflammatory mediators. Methods: Sputum was successfully induced in asthma patients (n=85) and healthy controls (n=21). Interle...
متن کاملCD163 expression in leukemia cutis.
BACKGROUND Proper diagnosis of myeloid leukemia cutis (LC) is of great clinical importance but can be difficult because no single immunohistochemical marker is adequately sensitive or specific for definitive diagnosis. Thus, a broader panel of markers is often desirable. CD163 is highly specific for normal and neoplastic cells of the monocyte/histiocyte lineage. In this study, we examined the v...
متن کاملAssignment of the CD163 antigen (CD163) to mouse chromosome 6 band F2 by radiation hybrid mapping.
The CD163 antigen is a member of the scavenger receptor cysteine rich (SRCR) protein family (Law et al., 1993). It is a type I membrane glycoprotein and has recently been identified as the macrophage receptor for hemoglobin-haptoglobin (HbHp) complexes (Kristiansen et al., 2001). By mediating the clearance of free hemoglobin the receptor may have a central role in hemoglobin and iron metabolism...
متن کاملCD163 and its role in inflammation.
Mononuclear phagocytes represent a heterogeneous population of cells with individual subpopulations exerting different pro- or anti-inflammatory functions. CD163 is a monocyte/macrophage specific marker expressed predominantly on cells which possess strong anti-inflammatory potential. The expression of CD163 is strongly induced by anti-inflammatory mediators such as glucocorticoids and interleu...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2004
ISSN: 0002-9173,1943-7722
DOI: 10.1309/qhd6yfn81kqxuuh6